Category: Cardiovascular, Diabetes and Metabolic Disorders

Friday, May 10, 2019 2:00 – 5:30pm, Hale Building for Transformative Medicine 

On Friday May 10^th, nearly 100 researchers and clinicians from over 20 institutions gathered at BWH to share ideas, promote cross-collaborative research efforts and identify new areas for further investigation to address the challenging public health crisis caused by obesity. This 8^th annual symposium commenced with short talks by selected junior speakers, all of whom received an award of $500. They were followed by keynote speaker, Caroline Apovian, MD, who gave an outstanding overview of the key research discoveries that have made significant contributions to the way obesity is treated in the clinic. This was followed by an electronic poster session featuring 30 presentations covering a broad range of research addressing many different aspects of obesity. Four posters stood out among the rest and were awarded prizes of $250.

This event is a great opportunity for investigators meet colleagues, learn what they are working on and set the foundation for future collaborations. If you were not able to join us this time, we hope to see you next year.

Keynote Speaker

Translating Obesity Research to the Practice of Obesity Medicine 

Caroline Apovian, MD, Professor of Medicine, Boston University School of Medicine 

Poster Winners

Leveraging Immunometabolic Control to Prevent and Treat Obesity Related Asthma

Furkan Burak, MD, Brigham and Women’s Hospital/Harvard T.H. Chan School of Public Health

Hepatocyte p53 ablation induces metabolic dysregulation that is corrected by food restriction and vertical sleeve gastrectomy

Bethany Cummings, DVM, PhD, Cornell University

Inhibiting Mitochondrial Fission Enhances Mitochondrial Respiratory Capacity and Insulin Signaling in Culture Myotubes Derived from Obese Humans

Benjamin Kugler, MS, University of Massachusetts Boston

The contribution of obesity to adult initiation of chronic prescription opioid use in the US: Results from MEPS, 2000 – 2015

Dielle Lundberg, Boston University School of Public Health

Selected Speakers

Fecal Microbiota Transplantation by Oral Capsules for the Treatment of Obesity: A Randomized, Placebo-Controlled Pilot Trials

Jessica Allegretti, MD, MPH, Assistant Professor of Medicine, Division of Gastroenterology, Brigham and Women’s Hospital

Identification of novel microbe-metabolome signatures associated with insulin sensitivity in mice

Jennifer Lee, PhD, Instructor in Medicine, Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center

Investigating how the source of dietary fat shapes the anti-chancer immune response in obesity

Lydia Lynch, PhD, Instructor in Medicine, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital

On Monday, March 26^th, clinicians and researchers convened at the 7^th Annual Obesity Incubator Session hosted by the Cardiovascular, Diabetes & Metabolic Disorders (CVDM) Research Center of the Brigham Research Institute to address the significant challenges associated with this public health crisis. The goal of the event was to promote cross-collaborative research and stimulate new ideas for further investigation in the fields of obesity, diabetes, and cardiovascular disease.

Keynote speaker, Dr. Rudy Leibel, Professor of Pediatrics and Medicine and Director of the New York Obesity Nutrition Research Center at Columbia University, has focused his research on the genetics of obesity and noninsulin-dependent diabetes. He delivered a thought provoking presentation describing the innovative methods his lab has employed using stem cells to elucidate the genetic basis of human metabolic diseases.  Special guest speaker, Dr. Rachel Carmody, Assistant Professor in Human Evolutionary Biology and Director of the Nutritional & Microbial Ecology Laboratory at Harvard University, captivated audiences with her research on the gut microbiome and how it responds to diet. Her unique perspective and approach to understanding human metabolism considers the human body as an ecosystem and combines experimental techniques from evolutionary biology, nutrition, physiology, microbiology, and metagenomics.

To begin this 7^th Annual Obesity Incubator, Dr. Leibel and Dr. Carmody’s presentations were preceded by three short talks selected from the research community: Instructor, Deirdre Tobias, Sc.D., from Brigham and Women’s Hospital and Harvard Medical School; Assistant Professor, Laura Holsen, Ph.D. from Brigham and Women’s Hospital and Harvard Medical School; Postdoctoral Fellow, J. Humberto Trevino-Villarreal, M.D., Ph.D., from Harvard School of Public Health.

The subsequent poster session featured ­­21 research projects from assistant professors, instructors, and postdoctoral researchers/clinical fellows. These posters displayed current work in obesity, diabetes, and cardiovascular disease, drawing in a large crowd of people that initiated many enthusiastic conversations among the scientific community. While the judges had a hard decision to make with the impressive breadth of abstracts, they, ultimately, chose to award three researchers that stood out among the rest; Postdoctoral Fellow ­­­­­­­­­­­­­Jingyi Qian, Ph.D. from Brigham and Women’s Hospital and Harvard Medical School, Postdoctoral Fellow Mehmet Furkan Burak, M.D. from Brigham and Women’s Hospital and Harvard Chan School of Public Health, and Instructor Samir Softic, M.D. from Brigham and Women’s Hospital and Boston Children’s Hospital.

Agenda

Invited Speakers

Dietary sensitivity of the gut microbiome: considerations for metabolic disease
Rachel Carmody, Ph.D., Assistant Professor of Human Evolutionary Biology, Harvard University

Stem cell-based strategies to elucidate human metabolic disease
Rudolph L. Leibel, MD., Professor of Pediatrics and Medicine, Columbia University

 

Selected Speakers

Circulating Branched-Chain Amino Acids and Incident Cardiovascular Disease in a Prospective Cohort of US Women
Deirdre K. Tobias*, Patrick R. Lawler, Paulo H. Harada, Olga V. Demler, Paul M Ridker, JoAnn E. Manson, Susan Cheng, Samia Mora

Hypothalamic and nucleus accumbens cerebral blood flow vary as a function of long-term carbohydrate-to-fat ratio diets
Laura M. Holsen*, Hilal Cerit, Belinda Lennerz, Scott Hoge, Taryn Hye, Priyanka Moondra, Jill M. Goldstein, Cara B. Ebbeling, and David Ludwig

Activation of an hepatic CREBH-ApoA5 axis increases peripheral VLDL-triglyceride clearance in response to dietary protein restriction
J Humberto Treviño-Villarreal*, Justin Reynolds, Alex Bartelt, Kent Langston, Michael MacArthur, Sarah Mitchell, Kaspar Trocha, Joerg Heeren, C. Keith Ozaki, Luigi Fontana, and James R. Mitchell

 Poster Winners

Sex differences in the effects of circadian misalignment on appetite hormones and substrate utilization
Jingyi Qian*, Rosanna Caputo, Christopher J Morris, Frank AJL Scheer

A Monoclonal anti- aP2 Antibody treats type 2 diabetes and Fatty Liver Disease
M. Furkan Burak*, Karen Inouye, Ariel White, Alexandra Lee, Gurol Tuncman, Ediz S. Calay, Motohiro Sekiya, Amir Tirosh, Kosei Eguchi, Gabriel Birrane, Helen Neale, Carl Doyle, Adrian Moore, and Gökhan S. Hotamisligil

Dietary Sugars Alter Fatty Acid Oxidation and Mitochondrial Function in Part Via Hyperacetylation of Mitochondrial Proteins in Liver
Samir Softic*, Jesse G. Meyer, Guo-Xiao Wang, Manoj K. Gupta, Hans P.M.M. Lauritzen, Shiho Fujisaka, Dolors Serra, Laura Herrero, Jennifer Willoughby, Kevin Fitzgerald, Olga Ilkayeva, Christopher B. Newgard, Bradford W. Gibson, Birgit Schilling, David E. Cohen, C. Ronald Kahn.

*Denotes that this person was the poster presenter/speaker