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News

Brigham IGNITE Launches

If a brilliant idea begins with a spark, it needs tinder to keep burning and, eventually, to catch on. The newly launched Brigham Ignite program is designed to help kindle and advance discoveries with clinical and commercial potential. Ignite works by guiding researchers through the development process, providing not just supportive funding, but also a team of experts in licensing, product development, intellectual property, and commercialization. The team can help principal investigators take the first steps onto the translational path and beyond.

Two of those team members — Glenn Miller, PhD, and Erin McKenna, MBA — recently spoke to CRN about what makes the Brigham Ignite program unique and what they hope to accomplish through its implementation. Miller is a market sector leader for Mass General Brigham Innovation who focuses on advisory services for faculty members to increase innovation across the hospital network. McKenna is an operating partner for Amplify (formerly the Translational Innovation Fund) and is leading the translation and project management efforts for Brigham Ignite. She brings experience from her work with the Boston Biomedical Innovation Center (B-BIC) and Boston Scientific.

Erin McKenna

Can you describe what Brigham Ignite is? What distinguishes it from other resources and awards?

EM: Ignite is more than just funding. It is a program that is being built to provide support for as wide a range of innovators as we can within the Brigham, to advise and consult with them on the ideas they have and help them determine whether there are paths forward from a product development standpoint, and if there’s potential for therapeutics, diagnostics or medical-device type ideas.

GM: The Ignite program is an umbrella program that helps any innovator within the

Glenn Miller

Brigham develop their idea to the fullest extent possible. This is really for everyone at the Brigham — anyone who has an idea that they think they might be able to commercialize, we’re here to help them do that. We’ll walk them through the process and evaluate whether or not the idea needs further development.

Who should work with Ignite?

EM: A range of innovators that have an idea. We assess that idea and determine if there’s a potential path forward from a product development standpoint.

For some people, we may be helping them create a first prototype or complete a first experiment that would help them get a little more evidence to show that their concept is viable.

We also envision finding innovators that are a little further along. They have developed their concepts. They have some evidence that shows that it’s viable. But they need some more help to move in a product commercialization direction. And that’s where our combination of funding and expert guidance can really help, not just in developing the technology, but making sure that we’re making the connections. You need to know that you are developing your technology in a direction that people will continue to pick up and invest in further to bring it out into the world.

GM: The program is not only for those people who think they already have a great idea, but also for those who are unclear about whether or not the idea they have is commercializable. We do receive a lot of questions from people saying, ‘I’m not quite sure this is patentable, but I think this could be very useful in the practice of medicine,’ for example, or they think it could increase productivity within a hospital, or could represent a process improvement or a digital health improvement.

Can you tell us more about the team?

EM: We have program managers coming in with industry product development experience to help investigators navigate the space of product development from an industry perspective. We will also have two focused licensing managers who will have their own portfolios of Brigham investigators. They will be serving to help bridge innovators to their supporting licensing manager and orient and navigate the space of thinking about innovation, disclosure, the patent process, and other types of agreements.

GM: The level of expertise of the people we’ve assembled and the years of experience they have, we’re measuring that in decades, not years. We’re bringing in heavy experience in doing out-licensing and starting new companies on the licensing side, managing industrial level programs large and small, and managing strategic approaches to commercialization and bringing products to market, from pharmaceuticals to diagnostics and devices. It’s a very broad and deep set of experience and expertise.

What are you most excited about as Ignite gets underway?

GM:  I got into the biopharmaceutical business to help people and the projects I’ve done over the course of my career have been aimed mainly at helping more and more people. The opportunity with this program is that it takes the ambitions of an entire, highly innovative hospital network and activates the minds within that network to improve medical care both within and outside of the four walls of the Brigham. It’s great to help patients at the Brigham. But the really exciting thing is that our community is changing how medicine is practiced beyond our hospital through their publications, products and commercialization efforts. Supporting those efforts is what really gets me going in the morning.

EM: At B-BIC, I really enjoyed the experience of working alongside innovators that had never been exposed to product development and commercialization, to not only help them navigate the space, but also see something move forward and emerge in the form of a startup or a licensed product. I’m really excited about being able to bring that experience to more innovators within the Brigham and collaborate more deeply with others.

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Event Recap News Obesity Research Incubator Session

3rd Annual Obesity Research Incubator Session

May 15, 2013 – 4PM – 6PM, Bornstein Amphitheatre and Cabot Atrium

The Cardiovascular, Diabetes and Metabolic Disorders Research Center at the Brigham Research Institute considers obesity to be a top research priority in accordance with the recent National Institutes of Health Strategic Plan for Obesity Research. The goal of this session is to bring together obesity and obesity-related comorbidities, to promote cross-collaborative research efforts, and to stimulate new ideas for further investigation as well as to address this challenge public health crisis through research.

With the goal of promoting vibrant scientific discussions, Gail Adler, MD, PhD, introduced the event, the first hour featured oral presentations on a few select themes in obesity research in the Bornstein Amphitheatre, and the second hour offered an interactive poster session on obesity research in the nearby Cabot Atrium.

Speakers

Targeting Start Domains in the Metabolic System

David E. Cohen, MD, PhD, Director of the Massachusetts General Hospital Weight Center and the Obesity Research Center at MGH, Robert H. Ebert Professor of Medicine and Health Sciences and Technology, Harvard Medical School

Gastrointestinal Regulation of Metabolic Function – Insights from Bariatric Surgery

Lee M. Kaplan, MD, PhD, Director of Hepatology, Brigham and Women’s Hospital, Associate Professor of Medicine, Harvard Medical School

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News

Submit Your Publication to Science Spotlight!

The Science Spotlight newsletter previously featured publications from Brigham researchers in high-impact journals collated by Harvard Paper Chase. This list has since been discontinued. Beginning in February 2021, papers from journals with the highest impact factors will be highlighted. Recognizing that journal impact factor is not an absolute way to feature all scientific publications of significant merit, we welcome investigators to submit noteworthy articles to be featured in the newsletter through this REDCap survey.

Sign up for the Events and Announcements newsletter here to receive Science Spotlight at the end of each month.

Please reach out to the Research Helpline with any additional questions or concerns.

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Discover Brigham Event Recap News

Highlights from Discover Brigham 2020

Thursday, November 12, 2019 11:00am – 4pm, Virtual Event

Discover Brigham was held virtually this year, the research, innovation and science at the Brigham was brought to life digitally by those who presented their captivating sessions, demos and posters.

Advancing science has never been more critical or time-sensitive as it is right now, given the global pandemic, but it has also never been so inspiring. Our researchers and scientists work every day to change and uplift the global conditions that have impacted our lives. In this year’s Discover Brigham, we came together to create an event that echoed the many strong voices heard around the world calling for change and progress.

On November 12th, the Brigham Research Institute hosted six exciting sessions, nine live demonstrations and featured close to 100 scientific posters at the poster session.

Agenda: Posters, Sessions & Demos

  • Poster Session & Demos
  • Rock the Mic: Postdoc Fast Pitch
  • What We Know About COVID-19
  • Hey Briggie: The use of Artificial Intelligence to Improve Patient Safety and Experience
  • Committing to Diversity, Inclusion and Equity in Clinical Research: The Time is Now
  • Getting Ahead: Advances in Food and Drug Allergy
  • What’s Sex Got To Do With It? Risk and Management of Autoimmune Disease
Ann Wooley, MD highlights the Brigham’s role in the COVID-19 Pandemic

Awards and Prize Winners

One of the sessions held at Discover Brigham was the exciting Postdoc Fast Pitch, during which four brave postdoctoral fellows pitched their projects to an audience. The $1,000 prize was decided by audience vote and the recipient of this prize was Jessica Williams, BS, MSc, PhD, a research fellow in Surgery and Cardiac Surgery who won with her project, “The Effect of Artery Shape on Patient Risk.”

Discover Brigham in the Media

This year, we were thrilled to see attendees from The Boston Globe, WBUR, Boston Herald, STAT News, and USA Today. The Boston Herald published an article highlighting the event, which was also featured on Channel 7 News.

Categories
Events Funding News

Shark Tank Awards Two Researchers

Congratulations to the Winners of the McGraw Family Opioid Awards!

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1st Place: $50,000

Christopher Connor, MD, PhD

Assistant Professor, Anesthesiology

Project: Imaging opioid effects, tolerance and addition in C. elegans

 

2nd Place: $25,000

William Renthal, MD, PhD

Assistant Professor, Neurology

Project: Targeted gene therapy for Chronic Pain

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Featured Image:

Top Left: Scott Weiner, MD, MPH

Top Right: Captain Robert McGraw

Bottom Left: William Renthal, MD, PhD

Bottom Right: Christopher Connor, MD, PhD

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Background on the Event:

Since 2012, Brigham & Women’s Hospital has been hosting shark tanks to fund innovative and high-risk/high impact projects in the basic, clinical, digital and translational realms through its Health & Technology Innovation Awards. Sponsored by the Brigham Research Institute (BRI) and the BWH Health & Technology Subcommittee, these awards aim to advance projects that have the potential to make an impact in one or more of the following domains – biomedical research, healthcare delivery, the generation of new companies/products/services, cost savings, care quality and provider burnout. Since 2012, more than $1 million has been distributed to BWH investigators through these awards.

This year, with the generous support of the McGraw Family, this cycle’s Request for Applications includes a special track focused on advancing innovations related to solving the opioid crisis which has resulted in the loss of over 2000 lives in the past year in Massachusetts alone. Novel ideas that seek to address questions and challenges related to the opioid epidemic including, but not limited to, research on addiction, adverse effects, alternate pain management strategies, genetic susceptibility to opioid abuse, new tools for opioid research, diagnosis/treatment, management of infectious diseases related to opioid abuse, withdrawal, personalized medicine were awarded.

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Categories
News

BRI Leadership Updates

October 2020

Originally published in Clinical and Research News (CRN) here:

“The Brigham Research Institute has announced that Ursula Kaiser, MD, chief of the Division of Endocrinology, Diabetes and Hypertension, assumed the role of BRI director on Oct. 1 while Marc Sabatine, MD, of the Division of Cardiovascular Medicine, will continue to advise and offer leadership in his formal role as past director. Sabatine is also chair of the Thrombolysis in Myocardial Infarction (TIMI) Study Group in the Division of Cardiovascular Medicine. Charles Serhan, PhD, DSc, director of the Center for Experimental Therapeutics and Reperfusion Injury in the Department of Anesthesiology, Perioperative and Pain Medicine, will serve as incoming co-director. Each leader of the BRI makes a six-year commitment to serving on the BRI Executive Committee, first as co-director for two years, then director for two years and finally as past director for two years. A list of previous past directors and their accomplishments is available here.”

Categories
Events Funding News

McGraw Opioid Innovator Award | Shark Tank Fall 2020

You’re Invited:

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Tuesday, October 20, 4:00 – 5:30pm, Zoom

Click Here to Register

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Since 2012, Brigham & Women’s Hospital has been hosting shark tanks to fund innovative and high-risk/high impact projects in the basic, clinical, digital and translational realms through its Health & Technology Innovation Awards. Sponsored by the Brigham Research Institute (BRI) and the BWH Health & Technology Subcommittee, these awards aim to advance projects that have the potential to make an impact in one or more of the following domains – biomedical research, healthcare delivery, the generation of new companies/products/services, cost savings, care quality and provider burnout. Since 2012, more than $1 million has been distributed to BWH investigators through these awards.

This year, with the generous support of the McGraw Family, this cycle’s Request for Applications includes a special track focused on advancing innovations related to solving the opioid crisis which has resulted in the loss of over 2000 lives in the past year in Massachusetts alone. Novel ideas that seek to address questions and challenges related to the opioid epidemic including, but not limited to, research on addiction, adverse effects, alternate pain management strategies, genetic susceptibility to opioid abuse, new tools for opioid research, diagnosis/treatment, management of infectious diseases related to opioid abuse, withdrawal, personalized medicine will be awarded.

Please note that this event is exclusively for Brigham and Women’s Hospital Staff and Mass General Brigham affiliates.

For more information, please contact bwhbri@partners.org

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Categories
Events Funding News

McGraw Family Opioid Innovator Awards | Fall 2020

We are excited to announce that Brigham & Women’s Hospital will host a Shark Tank event in Oct 2020 to fund two innovative and high-risk/high- impact projects in the basic, clinical, digital and translational realms through the McGraw Family Innovator Awards (open to opioid-related research).

Letter of Intent Due: Wednesday, July 22, 2020 | Click here to apply

RFA Due: Friday, September 11, 2020 | Click here for RFA details

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Scope: With the generous support of the McGraw Family, this year’s RFA will focus on advancing innovations related to solving the opioid crisis which has resulted in the loss of over 2000 lives a year for the past 3 years in Massachusetts alone. Novel ideas that seek to address questions and challenges related to the opioid epidemic including but not limited to research on addiction, adverse effects, alternate pain management strategies, genetic susceptibility to opioid abuse, new tools for opioid research, diagnosis/treatment, management of infectious diseases related to opioid abuse, withdrawal, personalized medicine etc. are welcome. Special focus on COVID-19 related research and racial and ethnic disparities research is also welcome.
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Awards: Up to two non-renewable grants will be awarded on a competitive basis with award denominations of up to $50,000 and $25,000 respectively.

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For more information, please contact:
Gloria Brand, MPA, Senior Program Manager
Program in Opioid and Pain Innovation
BWH
617-278-0516
gbrand@bwh.harvard.edu
Categories
News

Q&A with Paul Anderson, MD, PhD: Research and Innovation in the Time of COVID-19

Clinical and Research News (CRN) recently published a Q&A with Paul Anderson:

“In March, research leadership made an unprecedented decision. To help reduce the spread of COVID-19, the Brigham shut down the majority of its physical research labs. But that hasn’t stopped research teams from innovating. Labs that can do so are performing their work remotely, and labs that are performing essential functions, including COVID-19 research, are continuing their critical work on site.

Paul Anderson, MD, PhD, Senior Vice President of Research and Education, Chief Academic Office for the Brigham

Paul Anderson, MD, PhD, senior vice president of research and education and chief academic officer for the Brigham, recently answered questions about the laboratory shutdown, the launch of the Center for COVID Innovation and his hopes for the future.

In addition, the Brigham and Mass General research communities have come together to launch the Mass General Brigham Center for COVID Innovation (MGBCCI).

Paul Anderson, MD, PhD

Read the full conversation in Clinical and Research News here.

Categories
News

Coronavirus Projects Looking for Volunteers

COVID-19 Clinical Trials Looking for Volunteers

Discover a variety of clinical trial opportunities related to Coronavirus that you can volunteer for on the Rally for Research website.

Website: https://rally.partners.org/coronavirus 

If you would like to stay updated as new Coronavirus Disease (COVID-19) research opportunities become available, use this page to subscribe to the newsletter.

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